{"id":2470,"date":"2024-05-03T20:17:49","date_gmt":"2024-05-03T20:17:49","guid":{"rendered":"https:\/\/labs.cs.queensu.ca\/perklab\/members\/julia-wiercigroch\/"},"modified":"2024-05-03T20:17:49","modified_gmt":"2024-05-03T20:17:49","slug":"julia-wiercigroch","status":"publish","type":"qsc_member","link":"https:\/\/labs.cs.queensu.ca\/perklab\/members\/julia-wiercigroch\/","title":{"rendered":"Julia Wiercigroch"},"content":{"rendered":"<div class=\"wp-block-columns is-layout-flex wp-block-columns-is-layout-flex qsc-member-single-core-info-container\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow qsc-member-single-photo-column\">\n\t\t<img decoding=\"async\" src=\"https:\/\/labs.cs.queensu.ca\/perklab\/wp-content\/plugins\/qsc-members\/\/images\/missing-image-placeholder.png\" class=\"qsc-member-single-photo\"\/>\n\t<\/div>\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow qsc-member-single-info-column\">\n<div class=\"qsc-member-name\">\n<h1>Julia Wiercigroch<\/h1>\n<\/div>\n<div class=\"qsc-member-position\">Undergraduate Student<\/div>\n<div class=\"qsc-member-department\"><\/div>\n<div class=\"qsc-member-organization\">Queen&#8217;s University<\/div>\n<div class=\"qsc-member-date-range\">Member from <em>2018<\/em> to <em>present<\/em><\/div>\n<div class=\"qsc-member-contact\">\n<div class=\"qsc-member-socials\">\n\t\t\t<\/div>\n<\/p><\/div>\n<\/p><\/div>\n<\/div>\n<div class=\"qsc-member-bio\">\n<div class=\"teachpress_pub_list\"><form name=\"tppublistform\" method=\"get\"><a name=\"tppubs\" id=\"tppubs\"><\/a><\/form><div class=\"teachpress_publication_list\"><div class=\"tp_publication tp_publication_article\"><div class=\"tp_pub_info\"><p class=\"tp_pub_author\"> Wiercigroch, Julia;  Ungi, Tamas;  Idriss, Ahmedou Moulaye;  Tfeil, Yahya;  Kikinis, Ron;  Mousavi, Parvin;  Fichtinger, Gabor<\/p><p class=\"tp_pub_title\"><a class=\"tp_title_link\" href=\"https:\/\/www.spiedigitallibrary.org\/conference-proceedings-of-spie\/11598\/115980X\/Ultrasound-guided-needle-placement-system-optimized-for-translation-to-Mauritania\/10.1117\/12.2582012.short\" title=\"https:\/\/www.spiedigitallibrary.org\/conference-proceedings-of-spie\/11598\/115980X\/Ultrasound-guided-needle-placement-system-optimized-for-translation-to-Mauritania\/10.1117\/12.2582012.short\" target=\"blank\">Ultrasound-guided needle placement system optimized for translation to Mauritania<\/a> <span class=\"tp_pub_type tp_  article\">Journal Article<\/span> <\/p><p class=\"tp_pub_additional\"><span class=\"tp_pub_additional_in\">In: <\/span><span class=\"tp_pub_additional_volume\">vol. 11598, <\/span><span class=\"tp_pub_additional_pages\">pp. 239-244, <\/span><span class=\"tp_pub_additional_year\">2021<\/span>.<\/p><p class=\"tp_pub_menu\"><span class=\"tp_abstract_link\"><a id=\"tp_abstract_sh_1018\" class=\"tp_show\" onclick=\"teachpress_pub_showhide('1018','tp_abstract')\" title=\"Show abstract\" style=\"cursor:pointer;\">Abstract<\/a><\/span> | <span class=\"tp_resource_link\"><a id=\"tp_links_sh_1018\" class=\"tp_show\" onclick=\"teachpress_pub_showhide('1018','tp_links')\" title=\"Show links and resources\" style=\"cursor:pointer;\">Links<\/a><\/span> | <span class=\"tp_bibtex_link\"><a id=\"tp_bibtex_sh_1018\" class=\"tp_show\" onclick=\"teachpress_pub_showhide('1018','tp_bibtex')\" title=\"Show BibTeX entry\" style=\"cursor:pointer;\">BibTeX<\/a><\/span><\/p><div class=\"tp_bibtex\" id=\"tp_bibtex_1018\" style=\"display:none;\"><div class=\"tp_bibtex_entry\"><pre>@article{fichtinger2021r,<br \/>\r\ntitle = {Ultrasound-guided needle placement system optimized for translation to Mauritania},<br \/>\r\nauthor = {Julia Wiercigroch and Tamas Ungi and Ahmedou Moulaye Idriss and Yahya Tfeil and Ron Kikinis and Parvin Mousavi and Gabor Fichtinger},<br \/>\r\nurl = {https:\/\/www.spiedigitallibrary.org\/conference-proceedings-of-spie\/11598\/115980X\/Ultrasound-guided-needle-placement-system-optimized-for-translation-to-Mauritania\/10.1117\/12.2582012.short},<br \/>\r\nyear  = {2021},<br \/>\r\ndate = {2021-01-01},<br \/>\r\nvolume = {11598},<br \/>\r\npages = {239-244},<br \/>\r\npublisher = {SPIE},<br \/>\r\nabstract = {PURPOSE <br \/>\r\nPoint-of-care ultrasound image-guided therapies (POCUS IGT) transcend geographic and socioeconomic boundaries and help bringing modern therapies to underserved communities and countries. Unfortunately, current commercial systems are not feasible to deploy in Mauritania due to prohibitive costs of purchase, support, and operation. We present the development of a versatile POCUS IGT system, optimized for financial and operating conditions in Mauritania. We aimed to create a system that is functionally similar to the popular CIVCO product, but costs only a small fraction of the price due to the support of inexpensive ultrasound scanners and its use of open-source software. <br \/>\r\nMETHODS <br \/>\r\nA 3D-printed plastic needle guide with multiple guide channels was designed to securely fit around the ultrasound probe, placed in a sterile cover, and fitted with a sterile guide sleeve. Open source targeting \u2026},<br \/>\r\nkeywords = {},<br \/>\r\npubstate = {published},<br \/>\r\ntppubtype = {article}<br \/>\r\n}<br \/>\r\n<\/pre><\/div><p class=\"tp_close_menu\"><a class=\"tp_close\" onclick=\"teachpress_pub_showhide('1018','tp_bibtex')\">Close<\/a><\/p><\/div><div class=\"tp_abstract\" id=\"tp_abstract_1018\" style=\"display:none;\"><div class=\"tp_abstract_entry\">PURPOSE <br \/>\r\nPoint-of-care ultrasound image-guided therapies (POCUS IGT) transcend geographic and socioeconomic boundaries and help bringing modern therapies to underserved communities and countries. Unfortunately, current commercial systems are not feasible to deploy in Mauritania due to prohibitive costs of purchase, support, and operation. We present the development of a versatile POCUS IGT system, optimized for financial and operating conditions in Mauritania. We aimed to create a system that is functionally similar to the popular CIVCO product, but costs only a small fraction of the price due to the support of inexpensive ultrasound scanners and its use of open-source software. <br \/>\r\nMETHODS <br \/>\r\nA 3D-printed plastic needle guide with multiple guide channels was designed to securely fit around the ultrasound probe, placed in a sterile cover, and fitted with a sterile guide sleeve. Open source targeting \u2026<\/div><p class=\"tp_close_menu\"><a class=\"tp_close\" onclick=\"teachpress_pub_showhide('1018','tp_abstract')\">Close<\/a><\/p><\/div><div class=\"tp_links\" id=\"tp_links_1018\" style=\"display:none;\"><div class=\"tp_links_entry\"><ul class=\"tp_pub_list\"><li><i class=\"fas fa-globe\"><\/i><a class=\"tp_pub_list\" href=\"https:\/\/www.spiedigitallibrary.org\/conference-proceedings-of-spie\/11598\/115980X\/Ultrasound-guided-needle-placement-system-optimized-for-translation-to-Mauritania\/10.1117\/12.2582012.short\" title=\"https:\/\/www.spiedigitallibrary.org\/conference-proceedings-of-spie\/11598\/115980X\/[...]\" target=\"_blank\">https:\/\/www.spiedigitallibrary.org\/conference-proceedings-of-spie\/11598\/115980X\/[...]<\/a><\/li><\/ul><\/div><p class=\"tp_close_menu\"><a class=\"tp_close\" onclick=\"teachpress_pub_showhide('1018','tp_links')\">Close<\/a><\/p><\/div><\/div><\/div><div class=\"tp_publication tp_publication_conference\"><div class=\"tp_pub_info\"><p class=\"tp_pub_author\"> Wiercigroch, Julia;  Hashtrudi-Zaad, Keyvan;  Ungi, Tamas;  Bisleri, Gianluigi;  Fichtinger, Gabor<\/p><p class=\"tp_pub_title\"><a class=\"tp_title_link\" href=\"https:\/\/dx.doi.org\/https:\/\/doi.org\/10.1117\/12.2550160\" title=\"Force and torque feedback in endoscopic vessel harvesting\" target=\"blank\">Force and torque feedback in endoscopic vessel harvesting<\/a> <span class=\"tp_pub_type tp_  conference\">Conference<\/span> <\/p><p class=\"tp_pub_additional\"><span class=\"tp_pub_additional_booktitle\">Medical Imaging 2020: Image-Guided Procedures, Robotic Inverventions and Modeling, <\/span><span class=\"tp_pub_additional_volume\">vol. 11315, <\/span><span class=\"tp_pub_additional_organization\">SPIE <\/span><span class=\"tp_pub_additional_publisher\">SPIE, <\/span><span class=\"tp_pub_additional_address\">Houston, Texas, United States, <\/span><span class=\"tp_pub_additional_year\">2020<\/span>.<\/p><p class=\"tp_pub_menu\"><span class=\"tp_resource_link\"><a id=\"tp_links_sh_50\" class=\"tp_show\" onclick=\"teachpress_pub_showhide('50','tp_links')\" title=\"Show links and resources\" style=\"cursor:pointer;\">Links<\/a><\/span> | <span class=\"tp_bibtex_link\"><a id=\"tp_bibtex_sh_50\" class=\"tp_show\" onclick=\"teachpress_pub_showhide('50','tp_bibtex')\" title=\"Show BibTeX entry\" style=\"cursor:pointer;\">BibTeX<\/a><\/span><\/p><div class=\"tp_bibtex\" id=\"tp_bibtex_50\" style=\"display:none;\"><div class=\"tp_bibtex_entry\"><pre>@conference{Wiercigroch2020a,<br \/>\r\ntitle = {Force and torque feedback in endoscopic vessel harvesting},<br \/>\r\nauthor = {Julia Wiercigroch and Keyvan Hashtrudi-Zaad and Tamas Ungi and Gianluigi Bisleri and Gabor Fichtinger},<br \/>\r\nurl = {https:\/\/labs.cs.queensu.ca\/perklab\/wp-content\/uploads\/sites\/3\/2024\/02\/Wiercigroch2020a.pdf},<br \/>\r\ndoi = {https:\/\/doi.org\/10.1117\/12.2550160},<br \/>\r\nyear  = {2020},<br \/>\r\ndate = {2020-01-01},<br \/>\r\nurldate = {2020-01-01},<br \/>\r\nbooktitle = {Medical Imaging 2020: Image-Guided Procedures, Robotic Inverventions and Modeling},<br \/>\r\nvolume = {11315},<br \/>\r\npublisher = {SPIE},<br \/>\r\naddress = {Houston, Texas, United States},<br \/>\r\norganization = {SPIE},<br \/>\r\nkeywords = {},<br \/>\r\npubstate = {published},<br \/>\r\ntppubtype = {conference}<br \/>\r\n}<br \/>\r\n<\/pre><\/div><p class=\"tp_close_menu\"><a class=\"tp_close\" onclick=\"teachpress_pub_showhide('50','tp_bibtex')\">Close<\/a><\/p><\/div><div class=\"tp_links\" id=\"tp_links_50\" style=\"display:none;\"><div class=\"tp_links_entry\"><ul class=\"tp_pub_list\"><li><i class=\"fas fa-file-pdf\"><\/i><a class=\"tp_pub_list\" href=\"https:\/\/labs.cs.queensu.ca\/perklab\/wp-content\/uploads\/sites\/3\/2024\/02\/Wiercigroch2020a.pdf\" title=\"https:\/\/labs.cs.queensu.ca\/perklab\/wp-content\/uploads\/sites\/3\/2024\/02\/Wiercigroc[...]\" target=\"_blank\">https:\/\/labs.cs.queensu.ca\/perklab\/wp-content\/uploads\/sites\/3\/2024\/02\/Wiercigroc[...]<\/a><\/li><li><i class=\"ai ai-doi\"><\/i><a class=\"tp_pub_list\" href=\"https:\/\/dx.doi.org\/https:\/\/doi.org\/10.1117\/12.2550160\" title=\"Follow DOI:https:\/\/doi.org\/10.1117\/12.2550160\" target=\"_blank\">doi:https:\/\/doi.org\/10.1117\/12.2550160<\/a><\/li><\/ul><\/div><p class=\"tp_close_menu\"><a class=\"tp_close\" onclick=\"teachpress_pub_showhide('50','tp_links')\">Close<\/a><\/p><\/div><\/div><\/div><div class=\"tp_publication tp_publication_conference\"><div class=\"tp_pub_info\"><p class=\"tp_pub_author\"> Wiercigroch, Julia;  Baum, Zachary M C;  Ungi, Tamas;  Fritz, Jan;  Fichtinger, Gabor<\/p><p class=\"tp_pub_title\"><a class=\"tp_title_link\" href=\"https:\/\/labs.cs.queensu.ca\/perklab\/wp-content\/uploads\/sites\/3\/2024\/02\/Wiercigroch2019a.pdf\" title=\"https:\/\/labs.cs.queensu.ca\/perklab\/wp-content\/uploads\/sites\/3\/2024\/02\/Wiercigroch2019a.pdf\" target=\"blank\">Validation of a low-cost adjustable, handheld needle guide for spine interventions<\/a> <span class=\"tp_pub_type tp_  conference\">Conference<\/span> <\/p><p class=\"tp_pub_additional\"><span class=\"tp_pub_additional_booktitle\">SPIE Medical Imaging 2019: Image-Guided Procedures, Robotic Interventions, and Modeling, <\/span><span class=\"tp_pub_additional_volume\">vol. 10951, <\/span><span class=\"tp_pub_additional_address\">San Diego, California, <\/span><span class=\"tp_pub_additional_year\">2019<\/span>.<\/p><p class=\"tp_pub_menu\"><span class=\"tp_resource_link\"><a id=\"tp_links_sh_85\" class=\"tp_show\" onclick=\"teachpress_pub_showhide('85','tp_links')\" title=\"Show links and resources\" style=\"cursor:pointer;\">Links<\/a><\/span> | <span class=\"tp_bibtex_link\"><a id=\"tp_bibtex_sh_85\" class=\"tp_show\" onclick=\"teachpress_pub_showhide('85','tp_bibtex')\" title=\"Show BibTeX entry\" style=\"cursor:pointer;\">BibTeX<\/a><\/span><\/p><div class=\"tp_bibtex\" id=\"tp_bibtex_85\" style=\"display:none;\"><div class=\"tp_bibtex_entry\"><pre>@conference{Wiercigroch2019,<br \/>\r\ntitle = {Validation of a low-cost adjustable, handheld needle guide for spine interventions},<br \/>\r\nauthor = {Julia Wiercigroch and Zachary M C Baum and Tamas Ungi and Jan Fritz and Gabor Fichtinger},<br \/>\r\nurl = {https:\/\/labs.cs.queensu.ca\/perklab\/wp-content\/uploads\/sites\/3\/2024\/02\/Wiercigroch2019a.pdf},<br \/>\r\nyear  = {2019},<br \/>\r\ndate = {2019-03-01},<br \/>\r\nurldate = {2019-03-01},<br \/>\r\nbooktitle = {SPIE Medical Imaging 2019: Image-Guided Procedures, Robotic Interventions, and Modeling},<br \/>\r\nvolume = {10951},<br \/>\r\naddress = {San Diego, California},<br \/>\r\nkeywords = {},<br \/>\r\npubstate = {published},<br \/>\r\ntppubtype = {conference}<br \/>\r\n}<br \/>\r\n<\/pre><\/div><p class=\"tp_close_menu\"><a class=\"tp_close\" onclick=\"teachpress_pub_showhide('85','tp_bibtex')\">Close<\/a><\/p><\/div><div class=\"tp_links\" id=\"tp_links_85\" style=\"display:none;\"><div class=\"tp_links_entry\"><ul class=\"tp_pub_list\"><li><i class=\"fas fa-file-pdf\"><\/i><a class=\"tp_pub_list\" href=\"https:\/\/labs.cs.queensu.ca\/perklab\/wp-content\/uploads\/sites\/3\/2024\/02\/Wiercigroch2019a.pdf\" title=\"https:\/\/labs.cs.queensu.ca\/perklab\/wp-content\/uploads\/sites\/3\/2024\/02\/Wiercigroc[...]\" target=\"_blank\">https:\/\/labs.cs.queensu.ca\/perklab\/wp-content\/uploads\/sites\/3\/2024\/02\/Wiercigroc[...]<\/a><\/li><\/ul><\/div><p class=\"tp_close_menu\"><a class=\"tp_close\" onclick=\"teachpress_pub_showhide('85','tp_links')\">Close<\/a><\/p><\/div><\/div><\/div><div class=\"tp_publication tp_publication_conference\"><div class=\"tp_pub_info\"><p class=\"tp_pub_author\"> Asselin, Mark;  Kaufmann, Martin;  Wiercigroch, Julia;  Ungi, Tamas;  Lasso, Andras;  Rudan, John;  Fichtinger, Gabor<\/p><p class=\"tp_pub_title\">Navigated real-time molecular analysis in the operating theatre, demonstration of concept <span class=\"tp_pub_type tp_  conference\">Conference<\/span> <\/p><p class=\"tp_pub_additional\"><span class=\"tp_pub_additional_booktitle\">SPIE Medical Imaging 2019, <\/span><span class=\"tp_pub_additional_year\">2019<\/span>.<\/p><p class=\"tp_pub_menu\"><span class=\"tp_abstract_link\"><a id=\"tp_abstract_sh_74\" class=\"tp_show\" onclick=\"teachpress_pub_showhide('74','tp_abstract')\" title=\"Show abstract\" style=\"cursor:pointer;\">Abstract<\/a><\/span> | <span class=\"tp_bibtex_link\"><a id=\"tp_bibtex_sh_74\" class=\"tp_show\" onclick=\"teachpress_pub_showhide('74','tp_bibtex')\" title=\"Show BibTeX entry\" style=\"cursor:pointer;\">BibTeX<\/a><\/span><\/p><div class=\"tp_bibtex\" id=\"tp_bibtex_74\" style=\"display:none;\"><div class=\"tp_bibtex_entry\"><pre>@conference{Asselin2019a,<br \/>\r\ntitle = {Navigated real-time molecular analysis in the operating theatre, demonstration of concept},<br \/>\r\nauthor = {Mark Asselin and Martin Kaufmann and Julia Wiercigroch and Tamas Ungi and Andras Lasso and John Rudan and Gabor Fichtinger},<br \/>\r\nyear  = {2019},<br \/>\r\ndate = {2019-01-01},<br \/>\r\nurldate = {2019-01-01},<br \/>\r\nbooktitle = {SPIE Medical Imaging 2019},<br \/>\r\nabstract = {&lt;p&gt;&lt;strong&gt;PURPOSE&lt;\/strong&gt;: In the operating theatre surgeons are accustomed to using spatially navigated tools in conjunction with&lt;br \/&gt; <br \/>\r\nstandard clinical imaging during a procedure. This gives them a good idea where they are in the patients\u2019 anatomy but&lt;br \/&gt; <br \/>\r\ndoesn\u2019t provide information about the type of tissue they are dissecting. In this paper we demonstrate an integrated&lt;br \/&gt; <br \/>\r\nsystem consisting of a spatially navigated surgical electrocautery combined with real-time molecular analysis of the&lt;br \/&gt; <br \/>\r\ndissected tissue using mass spectrometry.&lt;br \/&gt; <br \/>\r\n&lt;strong&gt;METHODS&lt;\/strong&gt;: Using the 3D Slicer software package, we have integrated a commercially available neurosurgical&lt;br \/&gt; <br \/>\r\nnavigation system with an intra-operative mass spectrometer (colloquially referred to as the intelligent knife, or iKnife)&lt;br \/&gt; <br \/>\r\nthat analyzes the charged ions in the smoke created during cauterization. We demonstrate this system using a simulated&lt;br \/&gt; <br \/>\r\npatient comprised of an MRI scan from a brain cancer patient deformably registered to a plastic skull model. On the&lt;br \/&gt; <br \/>\r\nskull model we placed porcine and bovine tissues to simulate cancerous and healthy tissue, respectively. We built a&lt;br \/&gt; <br \/>\r\nPCA\/LDA model to distinguish between these tissue types. The tissue classifications were displayed in a spatially&lt;br \/&gt; <br \/>\r\nlocalized manner in the pre-operative imaging, in both 2D and 3D views.&lt;br \/&gt; <br \/>\r\n&lt;strong&gt;RESULTS&lt;\/strong&gt;: We have demonstrated the feasibility of performing spatially navigated intra-operative analysis of tissues by&lt;br \/&gt; <br \/>\r\nmass spectrometry. We show that machine learning can classify our sample tissues, with an average computed&lt;br \/&gt; <br \/>\r\nconfidence of 99.37 % for porcine tissue and 99.36% for bovine tissue.&lt;br \/&gt; <br \/>\r\n&lt;strong&gt;CONCLUSION&lt;\/strong&gt;: In this paper we demonstrate a proof of concept system for navigated intra-operative molecular&lt;br \/&gt; <br \/>\r\nanalysis. This system may enable intra-operative awareness of spatially localized tissue classification during dissection,&lt;br \/&gt; <br \/>\r\ninformation that is especially useful in tumor surgeries where margins may not be visible to the unassisted eye.&lt;br \/&gt; <br \/>\r\n&lt;strong&gt;Keywords&lt;\/strong&gt;: image guided therapy, intra-operative mass spectrometry, iKnife, 3D Slicer, open-source, rapid evaporative&lt;br \/&gt; <br \/>\r\nionization mass spectrometry (REIMS)&lt;\/p&gt;},<br \/>\r\nkeywords = {},<br \/>\r\npubstate = {published},<br \/>\r\ntppubtype = {conference}<br \/>\r\n}<br \/>\r\n<\/pre><\/div><p class=\"tp_close_menu\"><a class=\"tp_close\" onclick=\"teachpress_pub_showhide('74','tp_bibtex')\">Close<\/a><\/p><\/div><div class=\"tp_abstract\" id=\"tp_abstract_74\" style=\"display:none;\"><div class=\"tp_abstract_entry\">&lt;p&gt;&lt;strong&gt;PURPOSE&lt;\/strong&gt;: In the operating theatre surgeons are accustomed to using spatially navigated tools in conjunction with&lt;br \/&gt; <br \/>\r\nstandard clinical imaging during a procedure. This gives them a good idea where they are in the patients\u2019 anatomy but&lt;br \/&gt; <br \/>\r\ndoesn\u2019t provide information about the type of tissue they are dissecting. In this paper we demonstrate an integrated&lt;br \/&gt; <br \/>\r\nsystem consisting of a spatially navigated surgical electrocautery combined with real-time molecular analysis of the&lt;br \/&gt; <br \/>\r\ndissected tissue using mass spectrometry.&lt;br \/&gt; <br \/>\r\n&lt;strong&gt;METHODS&lt;\/strong&gt;: Using the 3D Slicer software package, we have integrated a commercially available neurosurgical&lt;br \/&gt; <br \/>\r\nnavigation system with an intra-operative mass spectrometer (colloquially referred to as the intelligent knife, or iKnife)&lt;br \/&gt; <br \/>\r\nthat analyzes the charged ions in the smoke created during cauterization. We demonstrate this system using a simulated&lt;br \/&gt; <br \/>\r\npatient comprised of an MRI scan from a brain cancer patient deformably registered to a plastic skull model. On the&lt;br \/&gt; <br \/>\r\nskull model we placed porcine and bovine tissues to simulate cancerous and healthy tissue, respectively. We built a&lt;br \/&gt; <br \/>\r\nPCA\/LDA model to distinguish between these tissue types. The tissue classifications were displayed in a spatially&lt;br \/&gt; <br \/>\r\nlocalized manner in the pre-operative imaging, in both 2D and 3D views.&lt;br \/&gt; <br \/>\r\n&lt;strong&gt;RESULTS&lt;\/strong&gt;: We have demonstrated the feasibility of performing spatially navigated intra-operative analysis of tissues by&lt;br \/&gt; <br \/>\r\nmass spectrometry. We show that machine learning can classify our sample tissues, with an average computed&lt;br \/&gt; <br \/>\r\nconfidence of 99.37 % for porcine tissue and 99.36% for bovine tissue.&lt;br \/&gt; <br \/>\r\n&lt;strong&gt;CONCLUSION&lt;\/strong&gt;: In this paper we demonstrate a proof of concept system for navigated intra-operative molecular&lt;br \/&gt; <br \/>\r\nanalysis. This system may enable intra-operative awareness of spatially localized tissue classification during dissection,&lt;br \/&gt; <br \/>\r\ninformation that is especially useful in tumor surgeries where margins may not be visible to the unassisted eye.&lt;br \/&gt; <br \/>\r\n&lt;strong&gt;Keywords&lt;\/strong&gt;: image guided therapy, intra-operative mass spectrometry, iKnife, 3D Slicer, open-source, rapid evaporative&lt;br \/&gt; <br \/>\r\nionization mass spectrometry (REIMS)&lt;\/p&gt;<\/div><p class=\"tp_close_menu\"><a class=\"tp_close\" onclick=\"teachpress_pub_showhide('74','tp_abstract')\">Close<\/a><\/p><\/div><\/div><\/div><div class=\"tp_publication tp_publication_article\"><div class=\"tp_pub_info\"><p class=\"tp_pub_author\"> Asselin, Mark;  Kaufmann, Martin;  Wiercigroch, Julia;  Ungi, Tamas;  Lasso, Andras;  Rudan, John;  Fichtinger, Gabor<\/p><p class=\"tp_pub_title\"><a class=\"tp_title_link\" href=\"https:\/\/www.spiedigitallibrary.org\/conference-proceedings-of-spie\/10951\/109512C\/Navigated-real-time-molecular-analysis-in-the-operating-theatre\/10.1117\/12.2512586.short\" title=\"https:\/\/www.spiedigitallibrary.org\/conference-proceedings-of-spie\/10951\/109512C\/Navigated-real-time-molecular-analysis-in-the-operating-theatre\/10.1117\/12.2512586.short\" target=\"blank\">Navigated real-time molecular analysis in the operating theatre: demonstration of concept<\/a> <span class=\"tp_pub_type tp_  article\">Journal Article<\/span> <\/p><p class=\"tp_pub_additional\"><span class=\"tp_pub_additional_in\">In: <\/span><span class=\"tp_pub_additional_volume\">vol. 10951, <\/span><span class=\"tp_pub_additional_pages\">pp. 618-624, <\/span><span class=\"tp_pub_additional_year\">2019<\/span>.<\/p><p class=\"tp_pub_menu\"><span class=\"tp_abstract_link\"><a id=\"tp_abstract_sh_883\" class=\"tp_show\" onclick=\"teachpress_pub_showhide('883','tp_abstract')\" title=\"Show abstract\" style=\"cursor:pointer;\">Abstract<\/a><\/span> | <span class=\"tp_resource_link\"><a id=\"tp_links_sh_883\" class=\"tp_show\" onclick=\"teachpress_pub_showhide('883','tp_links')\" title=\"Show links and resources\" style=\"cursor:pointer;\">Links<\/a><\/span> | <span class=\"tp_bibtex_link\"><a id=\"tp_bibtex_sh_883\" class=\"tp_show\" onclick=\"teachpress_pub_showhide('883','tp_bibtex')\" title=\"Show BibTeX entry\" style=\"cursor:pointer;\">BibTeX<\/a><\/span><\/p><div class=\"tp_bibtex\" id=\"tp_bibtex_883\" style=\"display:none;\"><div class=\"tp_bibtex_entry\"><pre>@article{fichtinger2019h,<br \/>\r\ntitle = {Navigated real-time molecular analysis in the operating theatre: demonstration of concept},<br \/>\r\nauthor = {Mark Asselin and Martin Kaufmann and Julia Wiercigroch and Tamas Ungi and Andras Lasso and John Rudan and Gabor Fichtinger},<br \/>\r\nurl = {https:\/\/www.spiedigitallibrary.org\/conference-proceedings-of-spie\/10951\/109512C\/Navigated-real-time-molecular-analysis-in-the-operating-theatre\/10.1117\/12.2512586.short},<br \/>\r\nyear  = {2019},<br \/>\r\ndate = {2019-01-01},<br \/>\r\nvolume = {10951},<br \/>\r\npages = {618-624},<br \/>\r\npublisher = {SPIE},<br \/>\r\nabstract = {PURPOSE <br \/>\r\nIn the operating theatre surgeons are accustomed to using spatially navigated tools in conjunction with standard clinical imaging during a procedure. This gives them a good idea where they are in the patients\u2019 anatomy but doesn\u2019t provide information about the type of tissue they are dissecting. In this paper we demonstrate an integrated system consisting of a spatially navigated surgical electrocautery combined with real-time molecular analysis of the dissected tissue using mass spectrometry. <br \/>\r\nMETHODS <br \/>\r\nUsing the 3D Slicer software package, we have integrated a commercially available neurosurgical navigation system with an intra-operative mass spectrometer (colloquially referred to as the intelligent knife, or iKnife) that analyzes the charged ions in the smoke created during cauterization. We demonstrate this system using a simulated patient comprised of an MRI scan from a brain cancer patient \u2026},<br \/>\r\nkeywords = {},<br \/>\r\npubstate = {published},<br \/>\r\ntppubtype = {article}<br \/>\r\n}<br \/>\r\n<\/pre><\/div><p class=\"tp_close_menu\"><a class=\"tp_close\" onclick=\"teachpress_pub_showhide('883','tp_bibtex')\">Close<\/a><\/p><\/div><div class=\"tp_abstract\" id=\"tp_abstract_883\" style=\"display:none;\"><div class=\"tp_abstract_entry\">PURPOSE <br \/>\r\nIn the operating theatre surgeons are accustomed to using spatially navigated tools in conjunction with standard clinical imaging during a procedure. This gives them a good idea where they are in the patients\u2019 anatomy but doesn\u2019t provide information about the type of tissue they are dissecting. In this paper we demonstrate an integrated system consisting of a spatially navigated surgical electrocautery combined with real-time molecular analysis of the dissected tissue using mass spectrometry. <br \/>\r\nMETHODS <br \/>\r\nUsing the 3D Slicer software package, we have integrated a commercially available neurosurgical navigation system with an intra-operative mass spectrometer (colloquially referred to as the intelligent knife, or iKnife) that analyzes the charged ions in the smoke created during cauterization. We demonstrate this system using a simulated patient comprised of an MRI scan from a brain cancer patient \u2026<\/div><p class=\"tp_close_menu\"><a class=\"tp_close\" onclick=\"teachpress_pub_showhide('883','tp_abstract')\">Close<\/a><\/p><\/div><div class=\"tp_links\" id=\"tp_links_883\" style=\"display:none;\"><div class=\"tp_links_entry\"><ul class=\"tp_pub_list\"><li><i class=\"fas fa-globe\"><\/i><a class=\"tp_pub_list\" href=\"https:\/\/www.spiedigitallibrary.org\/conference-proceedings-of-spie\/10951\/109512C\/Navigated-real-time-molecular-analysis-in-the-operating-theatre\/10.1117\/12.2512586.short\" title=\"https:\/\/www.spiedigitallibrary.org\/conference-proceedings-of-spie\/10951\/109512C\/[...]\" target=\"_blank\">https:\/\/www.spiedigitallibrary.org\/conference-proceedings-of-spie\/10951\/109512C\/[...]<\/a><\/li><\/ul><\/div><p class=\"tp_close_menu\"><a class=\"tp_close\" onclick=\"teachpress_pub_showhide('883','tp_links')\">Close<\/a><\/p><\/div><\/div><\/div><\/div><\/div><\/div>\n","protected":false},"featured_media":0,"template":"","meta":{"_acf_changed":false,"_uag_custom_page_level_css":"","site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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Member from 2018 to present Wiercigroch, Julia; Ungi, Tamas; Idriss, Ahmedou Moulaye; Tfeil, Yahya; Kikinis, Ron; Mousavi, Parvin; Fichtinger, GaborUltrasound-guided needle placement system optimized for translation to Mauritania Journal Article In: vol. 11598, pp. 239-244, 2021.Abstract | Links | BibTeX@article{fichtinger2021r, title = {Ultrasound-guided needle placement system optimized for 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