Profile – Perk Lab

Anna Ilina

Undergraduate Student

School of Computing

Queen's University

Anna was unergraduate research assistant in the Perk Lab and she has recently graduated from the Queen's Biomedical Computing program, graduarted in 2018

Jolley, MatthewA; Lasso, Andras; Nam, HannahH; Dinh, Patrick V.; Scanlan, Adam B.; Nguyen, Alexander V.; Ilina, Anna; Morray, Brian; Glatz, Andrew C.; McGowan, FrancisX; Whitehead, Kevin; Dori, Yoav; Gorman, Robert C.; Gorman, Robert C.; Fichtinger, Gabor; Gillespie, Matthew J.

Toward predictive modeling of catheter-based pulmonary valve replacement into native right ventricular outflow tracts Journal Article

In: Catheterization and Cardiovascular Interventions, 2018.

Abstract | Links | BibTeX

@article{doi:10.1002/ccd.27962,

title = {Toward predictive modeling of catheter-based pulmonary valve replacement into native right ventricular outflow tracts},

author = {MatthewA Jolley and Andras Lasso and HannahH Nam and Patrick V. Dinh and Adam B. Scanlan and Alexander V. Nguyen and Anna Ilina and Brian Morray and Andrew C. Glatz and FrancisX McGowan and Kevin Whitehead and Yoav Dori and Robert C. Gorman and Robert C. Gorman and Gabor Fichtinger and Matthew J. Gillespie},

url = {https://onlinelibrary.wiley.com/doi/abs/10.1002/ccd.27962},

doi = {10.1002/ccd.27962},

year  = {2018},

date = {2018-11-01},

urldate = {2018-11-01},

journal = {Catheterization and Cardiovascular Interventions},

abstract = {<p>Abstract Background Pulmonary insufficiency is a consequence of transannular patch repair in Tetralogy of Fallot (ToF) leading to late morbidity and mortality. Transcatheter native outflow tract pulmonary valve replacement has become a reality. However, predicting a secure, atraumatic implantation of a catheter-based device remains a significant challenge due to the complex and dynamic nature of the right ventricular outflow tract (RVOT). We sought to quantify the differences in compression and volume for actual implants, and those predicted by pre-implant modeling. Methods We used custom software to interactively place virtual transcatheter pulmonary valves (TPVs) into RVOT models created from pre-implant and post Harmony valve implant CT scans of 5 ovine surgical models of TOF to quantify and visualize device volume and compression. Results Virtual device placement visually mimicked actual device placement and allowed for quantification of device volume and radius. On average, simulated proximal and distal device volumes and compression did not vary statistically throughout the cardiac cycle (P = 0.11) but assessment was limited by small sample size. In comparison to actual implants, there was no significant pairwise difference in the proximal third of the device (P > 0.80), but the simulated distal device volume was significantly underestimated relative to actual device implant volume (P = 0.06). Conclusions This study demonstrates that pre-implant modeling which assumes a rigid vessel wall may not accurately predict the degree of distal RVOT expansion following actual device placement. We suggest the potential for virtual modeling of TPVR to be a useful adjunct to procedural planning, but further development is needed.</p>},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

Ilina, Anna; Pinter, Csaba; Lasso, Andras; Lai, Ingrid; Joshi, C. P.; Alexander, Kevin; Schreiner, L. John; Hanna, Timothy; Fichtinger, Gabor

3D Surface Scanning for Tumour Localization in Non-Melanoma Skin Cancer Conference

16th Annual Imaging Network Ontario Symposium (ImNO), Toronto, Canada, 2018.

Links | BibTeX

Ilina, Anna; Pinter, Csaba; Lasso, Andras; Lai, Ingrid; Joshi, C. P.; Alexander, Kevin; Schreiner, L. John; Hanna, Timothy; Fichtinger, Gabor

Target Definition with 3D Surface Scanning for Orthovoltage Radiation Therapy Planning Conference

CARS, Berlin, Germany, 2018.

Links | BibTeX

Ilina, Anna; Lasso, Andras; Jolley, MatthewA; Wohler, Brittany; Nguyen, Alexander V.; Scanlan, Adam B.; Baum, Zachary M C; McGowan, FrancisX; Fichtinger, Gabor

Patient-specific pediatric silicone heart valve models based on 3D ultrasound Conference

SPIE Medical Imaging 2017, vol. 10135, SPIE Medical Imaging SPIE Medical Imaging, Orlando, FL, United States, Feb. 16, 2017, 2017.

Abstract | Links | BibTeX

@conference{Ilina2017a,

title = {Patient-specific pediatric silicone heart valve models based on 3D ultrasound},

author = {Anna Ilina and Andras Lasso and MatthewA Jolley and Brittany Wohler and Alexander V. Nguyen and Adam B. Scanlan and Zachary M C Baum and FrancisX McGowan and Gabor Fichtinger},

url = {https://labs.cs.queensu.ca/perklab/wp-content/uploads/sites/3/2024/02/Ilina2017a.pdf},

year  = {2017},

date = {2017-03-01},

urldate = {2017-03-01},

booktitle = {SPIE Medical Imaging 2017},

volume = {10135},

publisher = {SPIE Medical Imaging},

address = {Orlando, FL, United States, Feb. 16, 2017},

organization = {SPIE Medical Imaging},

abstract = {<p>PURPOSE: Patient-specific heart and valve models have shown promise as training and planning tools for heart surgery, but physically realistic valve models remain elusive. Available proprietary, simulation-focused heart valve models are generic adult mitral valves and do not allow for patient-specific modeling as may be needed for rare diseases such as congenitally abnormal valves. We propose creating silicone valve models from a 3D-printed plastic mold as a solution that can be adapted to any individual patient and heart valve at a fraction of the cost of direct 3D-printing using soft materials.<br /> 

<br /> 

METHODS: Leaflets of a pediatric mitral valve, a tricuspid valve in a patient with hypoplastic left heart syndrome, and a complete atrioventricular canal valve were segmented from ultrasound images. A custom software was developed to automatically generate molds for each valve based on the segmentation. These molds were 3D-printed and used to make silicone valve models. The models were designed with cylindrical rims of different sizes surrounding the leaflets, to show the outline of the valve and add rigidity. Pediatric cardiac surgeons practiced suturing on the models and evaluated them for use as surgical planning and training tools.<br /> 

<br /> 

RESULTS: Five out of six surgeons reported that the valve models would be very useful as training tools for cardiac surgery. In this first iteration of valve models, leaflets were felt to be unrealistically thick or stiff compared to real pediatric leaflets. A thin tube rim was preferred for valve flexibility.<br /> 

<br /> 

CONCLUSION: The valve models were well received and considered to be valuable and accessible tools for heart valve surgery training. Further improvements will be made based on surgeons’ feedback.<br /> 

<br /> 

Keywords: surgery, training, heart valve models, pediatric, patient-specific, 3D-printing, congenital heart disease, mitral valve, tricuspid valve, complete atrioventricular canal defect, ultrasound</p>},

keywords = {},

pubstate = {published},

tppubtype = {conference}

}

PURPOSE: Patient-specific heart and valve models have shown promise as training and planning tools for heart surgery, but physically realistic valve models remain elusive. Available proprietary, simulation-focused heart valve models are generic adult mitral valves and do not allow for patient-specific modeling as may be needed for rare diseases such as congenitally abnormal valves. We propose creating silicone valve models from a 3D-printed plastic mold as a solution that can be adapted to any individual patient and heart valve at a fraction of the cost of direct 3D-printing using soft materials. 
 
METHODS: Leaflets of a pediatric mitral valve, a tricuspid valve in a patient with hypoplastic left heart syndrome, and a complete atrioventricular canal valve were segmented from ultrasound images. A custom software was developed to automatically generate molds for each valve based on the segmentation. These molds were 3D-printed and used to make silicone valve models. The models were designed with cylindrical rims of different sizes surrounding the leaflets, to show the outline of the valve and add rigidity. Pediatric cardiac surgeons practiced suturing on the models and evaluated them for use as surgical planning and training tools. 
 
RESULTS: Five out of six surgeons reported that the valve models would be very useful as training tools for cardiac surgery. In this first iteration of valve models, leaflets were felt to be unrealistically thick or stiff compared to real pediatric leaflets. A thin tube rim was preferred for valve flexibility. 
 
CONCLUSION: The valve models were well received and considered to be valuable and accessible tools for heart valve surgery training. Further improvements will be made based on surgeons’ feedback. 
 
Keywords: surgery, training, heart valve models, pediatric, patient-specific, 3D-printing, congenital heart disease, mitral valve, tricuspid valve, complete atrioventricular canal defect, ultrasound

Ilina, Anna; Lasso, Andras; Jolley, MatthewA; Wohler, Brittany; Nguyen, Alexander V.; Scanlan, Adam B.; Baum, Zachary M C; McGowan, FrancisX; Fichtinger, Gabor

Creating patient-specific anatomical models from highly elastic materials using 3D-printed molds Conference

15th Annual Imaging Network Ontario Symposium (ImNO), London, Canada, 2017.

Links | BibTeX