Attila Tanacs
Fichtinger, Gabor; Burdette, E. Clif; Tanacs, Attila; Patriciu, Alexandru; Mazilu, Dumitru; Whitcomb, Louis L.; Stoianovici, Dan
Robotically assisted prostate brachytherapy with transrectal ultrasound guidance–Phantom experiments Journal Article
In: Brachytherapy, vol. 5, no. 1, pp. 14–26, 2006.
@article{Fichtinger2006,
title = {Robotically assisted prostate brachytherapy with transrectal ultrasound guidance–Phantom experiments},
author = {Gabor Fichtinger and E. Clif Burdette and Attila Tanacs and Alexandru Patriciu and Dumitru Mazilu and Louis L. Whitcomb and Dan Stoianovici},
url = {http://dx doi org/10 1016/j brachy 2005 10 003
https://labs.cs.queensu.ca/perklab/wp-content/uploads/sites/3/2024/02/Fichtinger2006.pdf},
doi = {10 1016/j brachy 2005 10 003},
year = {2006},
date = {2006-01-01},
urldate = {2006-01-01},
journal = {Brachytherapy},
volume = {5},
number = {1},
pages = {14–26},
publisher = {Engineering Research Center, The Johns Hopkins University, Baltimore, MD 21218-2682, USA gabor@cs jhu edu},
abstract = {<p>PURPOSE: To report the preliminary experimental results obtained with a robot-assisted transrectal ultrasound (TRUS)-guided prostate brachytherapy system METHODS AND MATERIALS: The system consists of a TRUS unit, a spatially coregistered needle insertion robot, and an FDA-approved treatment planning, image-registered implant system The robot receives each entry/target coordinate pair of the implant plan, inserts a preloaded needle, and then the seeds are deposited The needles/sources are tracked in TRUS, thus allowing the plan to be updated as the procedure progresses RESULTS: The first insertion attempt was recorded for each needle, without adjustment All clinically relevant locations were reached in a prostate phantom Nonparallel, parallel needle trajectories were demonstrated Based on TRUS, the average transverse placement error was 2 mm (worst case 2 5 mm, 80% less than 2 mm), and the average sagittal error was 2 5 mm (worst case 5 0 mm, 70% less than 2 5 mm) CONCLUSIONS: The concept, technical viability of robot-assisted brachytherapy were demonstrated in phantoms The kinematically decoupled robotic assistant device is inherently safe Overall performance was promising, but further optimization is necessary to prove the possibility of improved dosimetry</p>},
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Fichtinger, Gabor; Burdette, Everette C; Tanacs, Attila; Patriciu, Alexandru; Mazilu, Dumitru; Whitcomb, Louis L; Stoianovici, Dan
Robotically assisted prostate brachytherapy with transrectal ultrasound guidance—Phantom experiments Journal Article
In: Brachytherapy, vol. 5, iss. 1, pp. 14-26, 2006.
@article{fichtinger2006c,
title = {Robotically assisted prostate brachytherapy with transrectal ultrasound guidance—Phantom experiments},
author = {Gabor Fichtinger and Everette C Burdette and Attila Tanacs and Alexandru Patriciu and Dumitru Mazilu and Louis L Whitcomb and Dan Stoianovici},
url = {https://www.sciencedirect.com/science/article/pii/S153847210600002X},
year = {2006},
date = {2006-01-01},
journal = {Brachytherapy},
volume = {5},
issue = {1},
pages = {14-26},
publisher = {Elsevier},
abstract = {PURPOSE
To report the preliminary experimental results obtained with a robot-assisted transrectal ultrasound (TRUS)–guided prostate brachytherapy system.
METHODS AND MATERIALS
The system consists of a TRUS unit, a spatially coregistered needle insertion robot, and an FDA-approved treatment planning and image-registered implant system. The robot receives each entry/target coordinate pair of the implant plan, inserts a preloaded needle, and then the seeds are deposited. The needles/sources are tracked in TRUS, thus allowing the plan to be updated as the procedure progresses.
RESULTS
The first insertion attempt was recorded for each needle, without adjustment. All clinically relevant locations were reached in a prostate phantom. Nonparallel and parallel needle trajectories were demonstrated. Based on TRUS, the average transverse placement error was 2mm (worst case 2.5mm, 80% less than …},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
To report the preliminary experimental results obtained with a robot-assisted transrectal ultrasound (TRUS)–guided prostate brachytherapy system.
METHODS AND MATERIALS
The system consists of a TRUS unit, a spatially coregistered needle insertion robot, and an FDA-approved treatment planning and image-registered implant system. The robot receives each entry/target coordinate pair of the implant plan, inserts a preloaded needle, and then the seeds are deposited. The needles/sources are tracked in TRUS, thus allowing the plan to be updated as the procedure progresses.
RESULTS
The first insertion attempt was recorded for each needle, without adjustment. All clinically relevant locations were reached in a prostate phantom. Nonparallel and parallel needle trajectories were demonstrated. Based on TRUS, the average transverse placement error was 2mm (worst case 2.5mm, 80% less than …
Susil, Robert; Krieger, Axel; Derbyshire, Andrew; Tanacs, Attila; Whitcomb, Louis L.; Fichtinger, Gabor; Atalar, Ergin
System for MR image-guided prostate interventions: canine study Journal Article
In: Radiology, vol. 228, no. 3, pp. 886–894, 2003.
@article{Susil2003,
title = {System for MR image-guided prostate interventions: canine study},
author = {Robert Susil and Axel Krieger and Andrew Derbyshire and Attila Tanacs and Louis L. Whitcomb and Gabor Fichtinger and Ergin Atalar},
url = {http://dx doi org/10 1148/radiol 2283020911
https://labs.cs.queensu.ca/perklab/wp-content/uploads/sites/3/2024/02/Susil2003.pdf},
doi = {10 1148/radiol 2283020911},
year = {2003},
date = {2003-09-01},
urldate = {2003-09-01},
journal = {Radiology},
volume = {228},
number = {3},
pages = {886–894},
abstract = {<p>The purpose of this study was to demonstrate the use of a transrectal system that enables precise magnetic resonance (MR) image guidance, monitoring of prostate interventions The system used a closed-bore 1 5-T MR imaging unit, enables one to take advantage of the higher signal-to-noise ratio achieved with traditional magnet designs, which is crucial for accurate targeting, monitoring of prostate interventions In the first of the four canine studies, reliable needle placement, with all needles placed within 2 mm of the desired target site, was achieved In two other studies, MR imaging was used to monitor distribution of injected contrast agent solution (gadopentetate dimeglumine mixed with trypan blue dye) in, around the prostate, thereby confirming that solution had been delivered to the desired tissue, also detecting faulty injections In the final study, accurate placement, MR imaging of brachytherapy seeds in the prostate were demonstrated The described system provides a flexible platform for a variety of minimally invasive MR image-guided therapeutic, diagnostic prostate interventions</p>},
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Fichtinger, Gabor; Susil, Robert; Krieger, Axel; Tanacs, Attila; Whitcomb, Louis L.; Atalar, Ergin
Prostate biopsy and local therapy inside conventional closed mri with robotic assistance - animal studies Journal Article
In: Journal of Academic Radiology, vol. 10, no. 8, pp. 955 - 955, 2003, ISSN: 1076-6332.
@article{Fichtinger2003c,
title = {Prostate biopsy and local therapy inside conventional closed mri with robotic assistance - animal studies},
author = {Gabor Fichtinger and Robert Susil and Axel Krieger and Attila Tanacs and Louis L. Whitcomb and Ergin Atalar},
url = {http://www sciencedirect com/science/article/B75BK-496D439-31/2/7aa2439d75eef1a22dca0f298c235db2
https://labs.cs.queensu.ca/perklab/wp-content/uploads/sites/3/2024/02/Fichtinger2003.pdf},
doi = {DOI: 10 1016/S1076-6332(03)00042-4},
issn = {1076-6332},
year = {2003},
date = {2003-01-01},
urldate = {2003-01-01},
journal = {Journal of Academic Radiology},
volume = {10},
number = {8},
pages = {955 - 955},
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Susil, Robert C; Krieger, Axel; Derbyshire, J Andrew; Tanacs, Attila; Whitcomb, Louis L; Fichtinger, Gabor; Atalar, Ergin
System for MR image–guided prostate interventions: canine study Journal Article
In: Radiology, vol. 228, iss. 3, pp. 886-894, 2003.
@article{fichtinger2003d,
title = {System for MR image–guided prostate interventions: canine study},
author = {Robert C Susil and Axel Krieger and J Andrew Derbyshire and Attila Tanacs and Louis L Whitcomb and Gabor Fichtinger and Ergin Atalar},
url = {https://pubs.rsna.org/doi/abs/10.1148/radiol.2283020911},
year = {2003},
date = {2003-01-01},
journal = {Radiology},
volume = {228},
issue = {3},
pages = {886-894},
publisher = {Radiological Society of North America},
abstract = {The purpose of this study was to demonstrate the use of a transrectal system that enables precise magnetic resonance (MR) image guidance and monitoring of prostate interventions. The system used a closed-bore 1.5-T MR imaging unit and enables one to take advantage of the higher signal-to-noise ratio achieved with traditional magnet designs, which is crucial for accurate targeting and monitoring of prostate interventions. In the first of the four canine studies, reliable needle placement, with all needles placed within 2 mm of the desired target site, was achieved. In two other studies, MR imaging was used to monitor distribution of injected contrast agent solution (gadopentetate dimeglumine mixed with trypan blue dye) in and around the prostate, thereby confirming that solution had been delivered to the desired tissue and also detecting faulty injections. In the final study, accurate placement and MR imaging of …},
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Susil, Robert; Krieger, Axel; Derbyshire, Andrew; Tanacs, Attila; McVeigh, Elliot; Whitcomb, Louis L.; Fichtinger, Gabor; Atalar, Ergin
A system for guidance and monitoring of transrectal prostate biopsy in a 1 5 T closed MR scanner Conference
European Radiology, vol. 12(9), 2002.
@conference{Susil2002,
title = {A system for guidance and monitoring of transrectal prostate biopsy in a 1 5 T closed MR scanner},
author = {Robert Susil and Axel Krieger and Andrew Derbyshire and Attila Tanacs and Elliot McVeigh and Louis L. Whitcomb and Gabor Fichtinger and Ergin Atalar},
year = {2002},
date = {2002-01-01},
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booktitle = {European Radiology},
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Fichtinger, Gabor; Krieger, Axel; Susil, Robert C; Tanacs, Attila; Whitcomb, Louis L; Atalar, Ergin
Transrectal prostate biopsy inside closed MRI scanner with remote actuation, under real-time image guidance Journal Article
In: pp. 91-98, 2002.
@article{fichtinger2002d,
title = {Transrectal prostate biopsy inside closed MRI scanner with remote actuation, under real-time image guidance},
author = {Gabor Fichtinger and Axel Krieger and Robert C Susil and Attila Tanacs and Louis L Whitcomb and Ergin Atalar},
url = {https://link.springer.com/chapter/10.1007/3-540-45786-0_12},
year = {2002},
date = {2002-01-01},
pages = {91-98},
publisher = {Springer Berlin Heidelberg},
abstract = {We present the proof-of-concept prototype of a prostate biopsy robot to be used inside a conventional high-field MRI scanner. A three degree-of-freedom (DOF) mechanical device translates and rotates inside the rectum and enters a needle into the body, and steers the needle to a target point pre-selected by the user. The device is guided by real-time images from the scanner. Networked computers process the medical images and enable the clinician to control the motion of the mechanical device that is operated remotely from outside the imager. The system is also applicable to localized prostate therapy and also demonstrates potential in other intra-cavitary procedures.},
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Fichtinger, Gabor; DeWeese, Theodore L; Patriciu, Alexandru; Tanacs, Attila; Mazilu, Dumitru; Anderson, James H; Masamune, Ken; Taylor, Russell H; Stoianovici, Dan
System for robotically assisted prostate biopsy and therapy with intraoperative CT guidance Journal Article
In: Academic radiology, vol. 9, iss. 1, pp. 60-74, 2002.
@article{fichtinger2002c,
title = {System for robotically assisted prostate biopsy and therapy with intraoperative CT guidance},
author = {Gabor Fichtinger and Theodore L DeWeese and Alexandru Patriciu and Attila Tanacs and Dumitru Mazilu and James H Anderson and Ken Masamune and Russell H Taylor and Dan Stoianovici},
url = {https://www.sciencedirect.com/science/article/pii/S1076633203802970},
year = {2002},
date = {2002-01-01},
journal = {Academic radiology},
volume = {9},
issue = {1},
pages = {60-74},
publisher = {Elsevier},
abstract = {RATIONALE AND OBJECTIVES
The purpose of this study was to assess the work-in-progress prototype of an image-guided, robotic system for accurate and consistent placement of transperineal needles into the prostate with intraoperative image guidance inside the gantry of a computed tomographic (CT) scanner.
MATERIALS AND METHODS
The coach-mounted system consists of a seven-degrees-of-freedom, passive mounting arm; a remote-center-of-motion robot; and a motorized, radiolucent needle-insertion device to deliver 17–18-gauge implant and biopsy needles into the prostate with the transperineal route. The robot is registered to the image space with a stereotactic adapter. The surgeon plans and controls the intervention in the CT scanner room with a desktop computer that receives DICOM images from the CT scanner. The complete system fits in a carry-on suitcase, does not need calibration, and …},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
The purpose of this study was to assess the work-in-progress prototype of an image-guided, robotic system for accurate and consistent placement of transperineal needles into the prostate with intraoperative image guidance inside the gantry of a computed tomographic (CT) scanner.
MATERIALS AND METHODS
The coach-mounted system consists of a seven-degrees-of-freedom, passive mounting arm; a remote-center-of-motion robot; and a motorized, radiolucent needle-insertion device to deliver 17–18-gauge implant and biopsy needles into the prostate with the transperineal route. The robot is registered to the image space with a stereotactic adapter. The surgeon plans and controls the intervention in the CT scanner room with a desktop computer that receives DICOM images from the CT scanner. The complete system fits in a carry-on suitcase, does not need calibration, and …
Susil, Robert; Krieger, Axel; Derbyshire, Andrew; Tanacs, Attila; McVeigh, Elliot; Whitcomb, Louis L.; Fichtinger, Gabor; Atalar, Ergin
A System for Guidance and Monitoring of Transrectal Prostate Biopsy in a 1 5 T Closed MR Scanner Conference
International Symposium of IVMRI, 2002.
@conference{Susil2002b,
title = {A System for Guidance and Monitoring of Transrectal Prostate Biopsy in a 1 5 T Closed MR Scanner},
author = {Robert Susil and Axel Krieger and Andrew Derbyshire and Attila Tanacs and Elliot McVeigh and Louis L. Whitcomb and Gabor Fichtinger and Ergin Atalar},
year = {2002},
date = {2002-01-01},
booktitle = {International Symposium of IVMRI},
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Susil, Robert; Derbyshire, Andrew; Krieger, Axel; Tanacs, Attila; Solaiyappan, Meiyappan; Whitcomb, Louis L.; McVeigh, Elliot; Fichtinger, Gabor; Atalar, Ergin
A Real-time MRI System for Guidance and Monitoring of Prostate Biopsy Conference
International Society of Magnetic Resonance Imaging in Medicine, Tenth Scientific Meeting, 2002.
@conference{Susil2002a,
title = {A Real-time MRI System for Guidance and Monitoring of Prostate Biopsy},
author = {Robert Susil and Andrew Derbyshire and Axel Krieger and Attila Tanacs and Meiyappan Solaiyappan and Louis L. Whitcomb and Elliot McVeigh and Gabor Fichtinger and Ergin Atalar},
year = {2002},
date = {2002-01-01},
urldate = {2002-01-01},
booktitle = {International Society of Magnetic Resonance Imaging in Medicine, Tenth Scientific Meeting},
pages = {2237},
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Krieger, Axel; Susil, Robert; Tanacs, Attila; Whitcomb, Louis L.; Fichtinger, Gabor; Atalar, Ergin
MRI Compatible Device for MRI Guided Transrectal Prostate Biopsy Conference
International Society of Magnetic Resonance Imaging in Medicine, Tenth Scientific Meeting, 2002.
@conference{Krieger2002,
title = {MRI Compatible Device for MRI Guided Transrectal Prostate Biopsy},
author = {Axel Krieger and Robert Susil and Attila Tanacs and Louis L. Whitcomb and Gabor Fichtinger and Ergin Atalar},
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Fichtinger, Gabor; Krieger, Axel; Susil, Robert; Tanacs, Attila; Whitcomb, Louis L.; Atalar, Ergin
Transrectal prostate biopsy inside closed MRI scanner with remote actuation and under real-time image guidance Journal Article
In: Lecture Notes in Computer Science Medical Image Computing and Computer-Assisted Intervention (MICCAI), vol. 2488 part 1, pp. 91-98, 2002.
@article{Fichtinger2002a,
title = {Transrectal prostate biopsy inside closed MRI scanner with remote actuation and under real-time image guidance},
author = {Gabor Fichtinger and Axel Krieger and Robert Susil and Attila Tanacs and Louis L. Whitcomb and Ergin Atalar},
url = {https://labs.cs.queensu.ca/perklab/wp-content/uploads/sites/3/2024/02/Fichtinger2002a.pdf},
year = {2002},
date = {2002-01-01},
urldate = {2002-01-01},
journal = {Lecture Notes in Computer Science Medical Image Computing and Computer-Assisted Intervention (MICCAI)},
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pages = {91-98},
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Fichtinger, Gabor; DeWeese, Theodore; Patriciu, Alexandru; Tanacs, Attila; Mazilu, Dumitru; Anderson, James; Masamune, Ken; Taylor, Russell H.; Stoianovici, Dan
Robotically Assisted Prostate Biopsy And Therapy With Intra-Operative CT Guidance Journal Article
In: Journal of Academic Radiology, vol. 9 no 1, pp. 60-74, 2002.
@article{Fichtinger2002,
title = {Robotically Assisted Prostate Biopsy And Therapy With Intra-Operative CT Guidance},
author = {Gabor Fichtinger and Theodore DeWeese and Alexandru Patriciu and Attila Tanacs and Dumitru Mazilu and James Anderson and Ken Masamune and Russell H. Taylor and Dan Stoianovici},
url = {https://labs.cs.queensu.ca/perklab/wp-content/uploads/sites/3/2024/02/Fichtinger2002a.pdf},
year = {2002},
date = {2002-01-01},
urldate = {2002-01-01},
journal = {Journal of Academic Radiology},
volume = {9 no 1},
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Fichtinger, Gabor; Masamune, Ken; Patriciu, Alexandru; Tanacs, Attila; Anderson, James; DeWeese, Theodore; Taylor, Russell H.; Stoianovici, Dan
Robotically Assisted Percutaneous Local Therapy and Biopsy Conference
Workshop proceedings of the Tenth IEEE International Conference of Advance Robotics, 2001.
@conference{Fichtinger2001b,
title = {Robotically Assisted Percutaneous Local Therapy and Biopsy},
author = {Gabor Fichtinger and Ken Masamune and Alexandru Patriciu and Attila Tanacs and James Anderson and Theodore DeWeese and Russell H. Taylor and Dan Stoianovici},
year = {2001},
date = {2001-01-01},
urldate = {2001-01-01},
booktitle = {Workshop proceedings of the Tenth IEEE International Conference of Advance Robotics},
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Fichtinger, Gabor; Xu, Sheng; Tanacs, Attila; Murphy, Kieran P; Myers, Lee; Williams, Jeffery
Approximate Volumetric Reconstruction from Projected Images Journal Article
In: Lecture Notes in Computer Science Medical Image Computing and Computer-Assisted Intervention (MICCAI), vol. 2208, pp. 416-424, 2001.
@article{Fichtinger2001a,
title = {Approximate Volumetric Reconstruction from Projected Images},
author = {Gabor Fichtinger and Sheng Xu and Attila Tanacs and Kieran P Murphy and Lee Myers and Jeffery Williams},
url = {https://labs.cs.queensu.ca/perklab/wp-content/uploads/sites/3/2024/02/Fichtinger2001a.pdf},
year = {2001},
date = {2001-01-01},
urldate = {2001-01-01},
journal = {Lecture Notes in Computer Science Medical Image Computing and Computer-Assisted Intervention (MICCAI)},
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Fichtinger, Gabor; Masamune, Ken; Patriciu, Alexandru; Tanacs, Attila; Anderson, James H; DeWees, T; Taylor, R; Stoianovici, Dan
Robotically assisted percutaneous local therapy and biopsy Journal Article
In: 10th International Conference of Advance Robotics, pp. 133-151, 2001.
@article{fichtinger2001d,
title = {Robotically assisted percutaneous local therapy and biopsy},
author = {Gabor Fichtinger and Ken Masamune and Alexandru Patriciu and Attila Tanacs and James H Anderson and T DeWees and R Taylor and Dan Stoianovici},
url = {https://scholar.google.com/scholar?cluster=6079521059264914675&hl=en&oi=scholarr},
year = {2001},
date = {2001-01-01},
journal = {10th International Conference of Advance Robotics},
pages = {133-151},
abstract = {We present the concept and prototype of an image-guided robotic system for accurate and consistent placement of percutaneous needles in soft tissue targets under CT-guidance. The system is a promising embodiment of the Surgical CAD/CAM paradigm and as such, easily adaptable to other image guidance modalities, like X-ray fluoroscopy. We also report the first results of pre-clinical experiments on phantoms.},
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Fichtinger, Gabor; Xu, Sheng; Tanacs, Attila; Murphy, Kieran; Myers, Lee; Williams, Jeffery
Approximate volumetric reconstruction from projected images Journal Article
In: pp. 1376-1378, 2001.
@article{fichtinger2001j,
title = {Approximate volumetric reconstruction from projected images},
author = {Gabor Fichtinger and Sheng Xu and Attila Tanacs and Kieran Murphy and Lee Myers and Jeffery Williams},
url = {https://link.springer.com/chapter/10.1007/3-540-45468-3_235},
year = {2001},
date = {2001-01-01},
pages = {1376-1378},
publisher = {Springer Berlin Heidelberg},
abstract = {A significant problem in planning of volumetrically prescribed localized treatments is the mathematical impossibility to determine the exact three dimensional shape and volume of a target object from its projected images. Reconstruction accuracy also varies with viewing angle, depending on the convexity and aspect ratios of the target object. In response to this problem, we are developing a robust and efficient technique for approximate volumetric reconstruction, which (A) uses no prior information of the shape and volume of the target, (B) does not require exact silhouettes, (C) accepts arbitrary number of images, (D) produces solid object and measure of its volume, (E) provides confidence measure of the reconstruction and drawing of silhouettes, (F) is robust, fast and easy to implement. Preliminary tests suggest that fairly convex objects can be reconstructed from four views, and typically six views with …},
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Sorantin, Erich; Balogh, Emese; Bartroli, Anna Vilanova; Palagyi, Kalman; Nyul, Laszlo G; Loncaric, Sven; Subasic, Marko; Kovacevic, Domagoj; Dudasne-Nagy, Marianna; Mate, Eors; Kari, Bela; Fichtinger, Gabor; DeWeese, Theodore L; Patriciu, Alexandru; Tanacs, Attila; Mazilu, Dumitru; Anderson, James H; Masamune, Ken; Taylor, Russel H; Stoianovici, Dan; Kuba, Attila; Balogh, Emese; Nyul, Laszlo G; Falcao, Alexandre X; Udupa, Jayaram K; Palagyi, Kalman; Sorantin, Erich; Halmai, Csongor; Erdohelyi, Balazs; Palagyi, Kalman; Nyul, Laszlo G; Olle, Krisztian; Geiger, Bernhard; Lindbichler, Franz; Friedrich, Gerhard; Kiesler, Karl
Virtual Dissection of the Colon Journal Article
In: 3D Image Processing–Techniques and Clinical Applications, vol. 21, pp. 263-273, 0000.
@article{fichtinger0000d,
title = {Virtual Dissection of the Colon},
author = {Erich Sorantin and Emese Balogh and Anna Vilanova Bartroli and Kalman Palagyi and Laszlo G Nyul and Sven Loncaric and Marko Subasic and Domagoj Kovacevic and Marianna Dudasne-Nagy and Eors Mate and Bela Kari and Gabor Fichtinger and Theodore L DeWeese and Alexandru Patriciu and Attila Tanacs and Dumitru Mazilu and James H Anderson and Ken Masamune and Russel H Taylor and Dan Stoianovici and Attila Kuba and Emese Balogh and Laszlo G Nyul and Alexandre X Falcao and Jayaram K Udupa and Kalman Palagyi and Erich Sorantin and Csongor Halmai and Balazs Erdohelyi and Kalman Palagyi and Laszlo G Nyul and Krisztian Olle and Bernhard Geiger and Franz Lindbichler and Gerhard Friedrich and Karl Kiesler},
url = {https://scholar.google.com/scholar?cluster=955860295717033248&hl=en&oi=scholarr},
journal = {3D Image Processing–Techniques and Clinical Applications},
volume = {21},
pages = {263-273},
publisher = {Springer Verlag},
abstract = {In this paper, we present a new mathematical method that synthesizes normal data sets for quantification of regional myocardium perfusion. In clinical practice, regional myocardial perfusion is often measured with a gamma camera and quantified via circumferential profile analysis. Normal reference profile data is used to increase the accuracy of the clinical interpretations. Our goal is to create reference data from an existing set of archived studies. An iterative mathematical method, based on two statistical hypotheses, was used to generate the study set instead of collecting normal examinations from a healthy population. Clinical validation is based on interpretations by six independent observers. Results of evaluation with synthesized normal data and its validation are presented.},
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