@conference{Wiercigroch2020a,

title = {Force and torque feedback in endoscopic vessel harvesting},

author = {Julia Wiercigroch and Keyvan Hashtrudi-Zaad and Tamas Ungi and Gianluigi Bisleri and Gabor Fichtinger},

url = {https://labs.cs.queensu.ca/perklab/wp-content/uploads/sites/3/2024/02/Wiercigroch2020a.pdf},

doi = {https://doi.org/10.1117/12.2550160},

year  = {2020},

date = {2020-01-01},

urldate = {2020-01-01},

booktitle = {Medical Imaging 2020: Image-Guided Procedures, Robotic Inverventions and Modeling},

volume = {11315},

publisher = {SPIE},

address = {Houston, Texas, United States},

organization = {SPIE},

keywords = {},

pubstate = {published},

tppubtype = {conference}

}

@conference{Wiercigroch2019,

title = {Validation of a low-cost adjustable, handheld needle guide for spine interventions},

author = {Julia Wiercigroch and Zachary M C Baum and Tamas Ungi and Jan Fritz and Gabor Fichtinger},

url = {https://labs.cs.queensu.ca/perklab/wp-content/uploads/sites/3/2024/02/Wiercigroch2019a.pdf},

year  = {2019},

date = {2019-03-01},

urldate = {2019-03-01},

booktitle = {SPIE Medical Imaging 2019: Image-Guided Procedures, Robotic Interventions, and Modeling},

volume = {10951},

address = {San Diego, California},

keywords = {},

pubstate = {published},

tppubtype = {conference}

}

@conference{Asselin2019a,

title = {Navigated real-time molecular analysis in the operating theatre, demonstration of concept},

author = {Mark Asselin and Martin Kaufmann and Julia Wiercigroch and Tamas Ungi and Andras Lasso and John Rudan and Gabor Fichtinger},

year  = {2019},

date = {2019-01-01},

urldate = {2019-01-01},

booktitle = {SPIE Medical Imaging 2019},

abstract = {<p><strong>PURPOSE</strong>: In the operating theatre surgeons are accustomed to using spatially navigated tools in conjunction with<br /> 

standard clinical imaging during a procedure. This gives them a good idea where they are in the patients’ anatomy but<br /> 

doesn’t provide information about the type of tissue they are dissecting. In this paper we demonstrate an integrated<br /> 

system consisting of a spatially navigated surgical electrocautery combined with real-time molecular analysis of the<br /> 

dissected tissue using mass spectrometry.<br /> 

<strong>METHODS</strong>: Using the 3D Slicer software package, we have integrated a commercially available neurosurgical<br /> 

navigation system with an intra-operative mass spectrometer (colloquially referred to as the intelligent knife, or iKnife)<br /> 

that analyzes the charged ions in the smoke created during cauterization. We demonstrate this system using a simulated<br /> 

patient comprised of an MRI scan from a brain cancer patient deformably registered to a plastic skull model. On the<br /> 

skull model we placed porcine and bovine tissues to simulate cancerous and healthy tissue, respectively. We built a<br /> 

PCA/LDA model to distinguish between these tissue types. The tissue classifications were displayed in a spatially<br /> 

localized manner in the pre-operative imaging, in both 2D and 3D views.<br /> 

<strong>RESULTS</strong>: We have demonstrated the feasibility of performing spatially navigated intra-operative analysis of tissues by<br /> 

mass spectrometry. We show that machine learning can classify our sample tissues, with an average computed<br /> 

confidence of 99.37 % for porcine tissue and 99.36% for bovine tissue.<br /> 

<strong>CONCLUSION</strong>: In this paper we demonstrate a proof of concept system for navigated intra-operative molecular<br /> 

analysis. This system may enable intra-operative awareness of spatially localized tissue classification during dissection,<br /> 

information that is especially useful in tumor surgeries where margins may not be visible to the unassisted eye.<br /> 

<strong>Keywords</strong>: image guided therapy, intra-operative mass spectrometry, iKnife, 3D Slicer, open-source, rapid evaporative<br /> 

ionization mass spectrometry (REIMS)</p>},

keywords = {},

pubstate = {published},

tppubtype = {conference}

}